Micromanagement of amino acid transporters

by Prof. Poul Nissen (Aarhus University)

Wednesday 10 Jun 2020, 15:15 → 16:15 Europe/Stockholm

Webcast

https://europeanspallationsource.se/article/2020/06/04/welcome-joint-ess-max-iv-science-colloquium-webcast-jun-10-micromanagement-amino

 

Biomembranes and membrane transport are fundamental components of life, establishing order in chaotic surroundings. Active transporters help compounds travel against (electro)chemical gradients to reach their goal. We study such transporters that couple uphill transport of amino acids and neurotransmitters with the downhill influx of Na+ into cells. Using serial synchrotron crystallography approaches we have determined structures of human and bacterial amino acid transporters and are also preparing for time-resolved studies. Aiming for analysis of hydrogen-bonding networks, we explore growth of large membrane protein crystals for neutron diffraction studies.