Speaker
Dr
Borislav Angelov
(Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, CZ-16206 Prague, Czech Republic)
Description
The formation of large nanochannels in cationic lipid cubosomes is demonstrated by cryogenic transmission electron microscopy (Cryo-TEM) and small-angle X-ray scattering (SAXS). The swollen cubic structure is stabilized by the polymer polyethylene glycol (PEG) and a cationic amphiphile. These cubosomes are of interest for multi-drug nanoencapsulation, mitochondrial mimetics, or nanocrystallization of membrane proteins. They possess high biocompatibility and biodegradability.
Primary author
Dr
Borislav Angelov
(Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, CZ-16206 Prague, Czech Republic)
Co-authors
Dr
Angelina Angelova
(CNRS UMR8612 Institut Galien Paris-Sud, Univ Paris Sud 11, F-92296 Châtenay-Malabry, France)
Dr
Markus Drechsler
(Laboratory for Soft Matter Electron Microscopy, Bayreuth Institute of Macromolecular Research, University of Bayreuth, D-95440 Bayreuth, Germany)
Dr
Petr Stepanek
(Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, CZ-16206 Prague, Czech Republic)
Dr
Rada Mutafchieva
(Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, BG-1113 Sofia, Bulgaria)
Dr
Sergey K. Filippov
(Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, CZ-16206 Prague, Czech Republic)
Dr
Vasyl M. Garamus
(Helmholtz-Zentrum Geesthacht, Centre for Materials and Coastal Research, D-21502 Geesthacht, Germany)
