Abstract
The 2022 Nobel Prize in Chemistry was awarded for Click Chemistry – a powerful concept that enables the linking of fully functional molecules to build molecular robots and establish accurately architectured macro-structures with targeted properties.
This presentation will introduce Click Chemistry from both mechanistic and innovation perspectives. We work on a variety of chronic disease–related bio-macromolecules with peptidomimetics in which triazole formation plays a pivotal role. These include molecules involved in the microenvironment of Alzheimer’s plaques and cancer cells.
A novel intramolecular click-like reaction used in converting peptide diversity into small-molecule scaffolds will also be presented. In this context, our current systems of education, funding and research planning will be discussed, and how these influence the pathway from discovery to innovation.
About the speaker
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Professor Morten Meldal Morten Meldal is a Danish chemist and Professor at the Department of Chemistry at the University of Copenhagen. He was awarded the 2022 Nobel Prize in Chemistry, together with Barry Sharpless and Carolyn Bertozzi, for the groundbreaking development of click chemistry and bioorthogonal chemistry. Throughout his career, Prof. Meldal’s research has had a transformative impact on peptide and combinatorial chemistry. His contributions to solid-phase and combinatorial peptide synthesis, as well as his development of the CuAAC click reaction, have become foundational methods widely used in bioorganic and organic synthesis. |
Prof. Morten Meldal
Photo: Lars Krabbe |
Organised by ESS & LINXS
For questions, please contact: Raquel Costa (raquel.costa@ess.eu)
