Description
Microbial polyketides are biosynthesized by large multi-modular enzymes termed polyketide synthases (PKSs) that assemble the polyketide backbones from simple carboxylic extender units. The PKS gene clusters mostly include associated regulators such as transcription regulators that coordinate and control the expression of the biosynthesis genes. Contrast variation SANS has enabled us to gain important insights into the molecular mechanisms controlling these protein-DNA interactions.
Primary author
Nathan Zaccai
(Cambridge University)
